Table 7:
Treatment Response After MRgFUS Capsulotomy
| Author, year | Time point | Responders, % (n) | Partial responders, % (n) | Remission, % (n) | Nonresponders, % (n) |
|---|---|---|---|---|---|
| Davidson et al, 202072 | Last follow-upa | 66.7 (4) | NR | NR | 33.3 (2) |
| Kim et al, 201879 | 12 mo | 54.5 (6)b | 27.3 (3)c | - | 18.2 (2) |
| 24 mo | 54.5 (6) | 18.2 (2) | 9.1 (1)d | 18.2 (2) |
Abbreviations: MRgFUS, magnetic resonance-guided focused ultrasound; NR, not reported.
a
For 4 patients, this was 12 at months, and for the other 2 patients, this was at 6 months, as they had not yet reached 12 months since MRgFUS capsulotomy.72
b
Defined as ≥35% reduction from baseline Y-BOCS score and much or very much improved on CGI—I (i.e., rating of 1 or 2).79
c
Defined as 25% to 35% reduction from baseline Y—BOCS score and minimally improved on CGI—I (i.e., rating ≥ 3).79
d
Defined as Y-BOCS score ≤ 12 and normal or borderline mentally ill on CGI-S (i.e., rating of 1 or 2).79