Table 2a.
Periodic clinical, haematological, and biochemical evaluation of the patient's radiological.
|
Status and duration of OAM→ |
Beginning of OAM and ongoing chemotherapy |
End of chemotherapy |
1 Y |
2 Y |
3 Y |
4 Y |
5 Y |
6 Y |
7 Y |
8 Y |
9 Y |
10 Y |
11 Y |
12 Y |
13Y |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Month/Year → | June 2011 | Aug 2011 | 2012 | 2013 | 2014 | 2015 | 2016 | 2017 | 2018 | 2019 | 2020 | 2021 | 2022 | 2023 | 2024 |
| A) Clinical parameters | |||||||||||||||
| Weakness | 2 | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Dysphagia | 2 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| Dysuria | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Stomatitis | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| PR bleeding | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Constipation | 2 | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Black stool | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Leg Pain | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Loss of appetite | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Trismus | 3 | 2 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| Indistinct speech | 3 | 3 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 1 | 1 | 1 |
| B/L LL Neuritis | 1 | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Pain | 6 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Weight (Kg) | 65 | 55 | 59 | 65 | 67.6 | 65.4 | 63.3 | 62.5 | 64.2 | 63.6 | 62.9 | 64.3 | 63.5 | 63.4 | 65.4 |
| Karnofsky Performance Score (KPS) | 80 | 80 | 80 | 100 | 90 | 100 | 100 | 90 | 100 | 100 | 90 | 100 | 100 | 100 | 100 |
| Functional Score from QLQ C30 | 73.33 | 93.33 | 93.33 | 86.67 | 86.67 | 84.4 | 100 | 80 | 77.78 | 75.56 | 80 | 80 | 75.56 | 88.89 | 73.33 |
| Symptom Score from QLQ C30 | 28.20 | 12.82 | 12.82 | 5.21 | 5.21 | 7.69 | 0 | 10.26 | 12.82 | 12.82 | 15.38 | 28.20 | 20.51 | 2.56 | 17.95 |
| Global Score from QLQ C30 | 41.67 | 58.33 | 58.33 | 83.3 | 83.3 | 83.3 | 83.33 | 83.3 | 66.67 | 66.67 | 75 | 58.33 | 66.67 | 66.67 | 83.33 |
| QLQ H&N 35 | 123.08 | 76.92 | 76.92 | 84.62 | 92.31 | 87.18 | 53.85 | 92.31 | 92.31 | 97.44 | 100 | 97.44 | 120.51 | 97.44 | 115.8 |
| B) Haematological parameters | |||||||||||||||
| Hb ∗(12–16 g/dl) | 12.40 | 10.50 | 12.60 | – | 13.8 | 12.7 | 12.20 | 12.6 | 12.70 | 13.2 | – | – | 13.0 | 13.40 | 13.6 |
| WBC ∗(4000–11000/cmm) | 3700 | 19800 | 5300 | – | 6640 | 6400 | 6700 | 5700 | 6300 | 6700 | – | – | 6000 | 6350 | 5100 |
| Platelets ∗(150–450 x 103/cmm) | 252 | 329 | 203 | – | 238 | 221 | 220 | 254 | 237 | 255 | – | – | 238 | 260 | 280 |
| S. Bilirubin ∗(0–1.2 mg/dl) | 0.93 | 0.76 | – | – | 0.78 | – | 0.5 | 0.55 | – | – | – | – | – | 1.09 | – |
| SGOT ∗(0–31 U/L) | 28 | 27 | – | – | 24.1 | – | 17 | 14.3 | – | – | – | – | – | 16.76 | – |
| SGPT ∗(0–32 U/L) | 30 | 26 | – | – | 22.6 | – | 19 | 18.1 | – | – | – | – | – | 12.15 | – |
| S. Alkaline phosphatase ∗(44–147 U/L) | 62 | 93 | – | – | 76.9 | – | 102 | 88.1 | – | – | – | – | – | 104.62 | – |
| S. Creatinine ∗(0.7–1.7 mg/dl) | 0.8 | 0.8 | – | – | – | – | 0.90 | 0.90 | 0.90 | 0.90 | – | – | 1.22 | 0.76 | 0.99 |
| Total Cholesterol ∗(130–220 mg/dl) | – | – | – | – | 181 | 202 | 191 | 202 | 213 | 207 | – | – | 200 | 235.55 | 228 |
| HDL ∗(35–55 mg/dl) | – | – | – | – | 50.90 | 50.8 | 60.6 | 50 | 51.2 | 56.2 | – | – | – | 56.15 | 42 |
| LDL ∗(110–140 mg/dl) | – | – | – | – | 106 | 125 | 107 | 132 | 138 | 123 | – | – | – | 161.69 | 159.6 |
| Triglycerides ∗(50–200 mg/dl | – | – | – | – | 119 | 132 | 119 | 98 | 119 | 137 | – | – | – | 88.54 | 132 |
| Total T3 ∗(70–204 ng/dL), T3 ∗(0.58–1.59 ng/mL) | – | 0.76 | 76.40 | 0.78 | 122 | – | 0.982 | 81 | 0.976 | – | – | 0.80 | 2.25 | 0.805 | |
| T4 ∗(5.13–14.06 μg/dl) | – | 4.28 | 4.50 | 5.61 | 8.15 | – | 7.79 | – | 8.0 | 7.19 | – | – | 6.38 | 1.27 | 7.71 |
| TSH ∗(0.4–4.0 mIU/dl) | – | 26.20 | 33.750 | 7.04 | 5.070 | – | 1.77 | – | 1.710 | 2.33 | – | – | 8.64 | 8.67 | 11.31 |
| FBS ∗(70–110 mg/dl) | 116 | 151 | 95 | – | 109 | 117 | 96 | 99 | 110 | 119 | – | – | 131 | 134.81 | 124 |
∗Indicates normal range of haematological and biochemical parameters.