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. 2025 May 27;15:1588646. doi: 10.3389/fonc.2025.1588646

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Copyright © 2025 Luo, Liu, Peng, Zhao, Li, Cai, Lei, Zhang and Zhao

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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GNG7 inhibits LUAD cell proliferation and induces apoptosis. (A, B) qPCR shows GNG7 is downregulated in LUAD tissues and cell lines (P<0.05, P<0.01). (C) Western blot confirms decreased GNG7 protein in A549/H1299 cells (P<0.001). (D–G) GNG7 overexpression increases mRNA and protein levels (P<0.05). (H, K) CCK-8 assays show reduced proliferation with GNG7 overexpression. (I, L) WB reveals increased BAX and decreased BCL-2 levels (P<0.05). (J, M) Flow cytometry confirms increased apoptosis in GNG7-overexpressing cells (P<0.01). *p<0.05, **p<0.01, ***p<0.001.