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. 2025 May 27;15:1588646. doi: 10.3389/fonc.2025.1588646

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Copyright © 2025 Luo, Liu, Peng, Zhao, Li, Cai, Lei, Zhang and Zhao

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Construction and validation of a GNG7-based LUAD prognostic risk model. (A, B) LASSO Cox regression identifies 11 prognostic genes from TCGA LUAD cohort. (C) Kaplan–Meier curve shows significantly better OS in the low-risk group (P<0.0001). (D) ROC curves for 1-, 3-, and 5-year OS show strong predictive performance. (E, F) GSE31210 validation confirms model reliability (KM P=0.00029; AUCs: 1-year=0.75, 3-year=0.75, 5-year=0.76). ROC, receiver operating characteristic; AUC, area under the curve.