Table 3.
Selected studies evaluating scarring alopecia outcomes following IL-23 inhibitor use
Author | Indication | Enrollment | Study Drug Regimen | Concurrent Therapies | Outcomes |
---|---|---|---|---|---|
Nagshabandi et al. [32] | DC | 2 | Risankizumab, in-clinic injection every 3 months |
Patient 1: Not reported Patient 2: Topical clindamycin 1% solution daily |
At 13-month follow-up, patient 1 reported improvement of roughly 70% in scalp lesions by the fifth dose, with no new lesions or draining nodules; signs of hair growth evident At four-month follow-up, patient 2 experienced improvements in skin lesions by the third dose |
Awad et al. [33] | DC | 1 | Tildrakizumab, two doses of subcutaneous injection given 4 weeks apart | Not reported |
At eight-week follow-up, the patient increased hair density and reduced the number of pustules Patient reported alleviated scalp tenderness and hair regrowth |
Trindade de Carvalho et al. [34] | FFA/LPP | 1 | Tildrakizumab, 100 mg subcutaneously at weeks 0, 4, and subsequently 12 weekly | Minoxidil 1–2 mg/day and dutasteride 0.5 mg/day |
At 16-week follow-up, patient experienced symptomatic improvements At 13-month follow-up, remission was maintained No adverse reactions reported |