Table 1.
Compounds inhibiting 50% or more of the growth of Cr. neoformans H99 and Ca. auris MMC2 in the Pharmakon 1600 compound collection.*
| Growth inhibition (%) | |||
|---|---|---|---|
| Compound | Original reported activity | Cr. neoformans H99 | Ca. auris MMC2 |
| Dichlorophen | Anthelmintic | 84.3 | 70.6 |
| Triclabendazole | Anthelmintic | 84.1 | 53 |
| Bithionate sodium | Anthelmintic, antiseptic | 98.4 | 74.6 |
| Iodoquinol | Antiamebic | 94.5 | 96.2 |
| Alexidine hydrochloride | Antibacterial (topical mouthwashes) | 100 | 55.1 |
| Pyrithione zinc | Antibacterial, antifungal, Antiseborrheic (topical) | 100 | 100 |
| Amphotericin B | Antifungal | 100 | 99.1 |
| Butoconazole | Antifungal | 100 | 98.4 |
| Ciclopirox olamine | Antifungal | 100 | 99.6 |
| Climbazole | Antifungal | 87.4 | 91.7 |
| Clotrimazole | Antifungal | 90.4 | 96.5 |
| Econazole nitrate | Antifungal | 93.2 | 91 |
| Enilconazole sulfate | Antifungal | 60.5 | 88.7 |
| Fluconazole | Antifungal | 74.4 | 91.5 |
| Itraconazole hydrochloride | Antifungal | 69.7 | 85.7 |
| Ketoconazole | Antifungal | 90.4 | 95.8 |
| Miconazole nitrate | Antifungal | 98 | 97 |
| Oxiconazole nitrate | Antifungal | 100 | 92.1 |
| Sulconazole nitrate | Antifungal | 100 | 98.1 |
| Terbinafine hydrochloride | Antifungal | 83.3 | 65.6 |
| Terconazole | Antifungal | 82.5 | 96.7 |
| Tioconazole | Antifungal | 90.8 | 90.8 |
| Voriconazole | Antifungal | 83.6 | 94.8 |
| Phenylmercuric acetate | Antifungal, antimicrobial | 100 | 99.3 |
| Cetylpyridinium chloride | Antiinfectant (topical) | 100 | 100 |
| Dequalinium chloride | Antiinfectant, antineoplasic | 98.6 | 86.8 |
| Broxyquinoline | Antiinfectant, disinfectant | 99.5 | 100 |
| Methylbenzethonium chloride | Antiinfective (topical) | 100 | 61.4 |
| Hexachlorophene | Antiinfective (topical) | 100 | 64 |
| Bleomycin sulfate | Antineoplastic | 94.1 | 94.3 |
| Ebselen | Antioxidant, lipoxygenase inhibitor, inhibits oxidation of LDL | 84.3 | 99.9 |
| Pentamidine isethionate | Antiprotozoal; inhibits nucleic acid and protein synthesis | 98 | 90.9 |
| Cycloheximide | Antipsoriatic, protein synthesis inhibitor | 100 | 92.8 |
| Piroctone olamine | Antiseborrheic (topical) | 100 | 99.3 |
| Clioquinol | Antiseptic, antiamebic | 99.7 | 98.8 |
| Chloroxine | Chelating agent, antiseborrheic (topical) | 100 | 99.6 |
| Thonzonium bromide | Mucolytic, antibacterial, surface active agent | 100 | 99.4 |
| Suloctidil | Peripheral vasodilator | 51.2 | 62.4 |
*
For information on the selection of compounds for further testing, see the Results section.