Table 2. Top ten inter-omic analyte pair associations modified by each APOE and delta age status, stratified by sex.
| APOE Status | |||||||||||
| Female APOE E2 | Female APOE E4 | Male APOE E2 | Male APOE E4 | ||||||||
| ++ | BMP6 | N-palmitoylglycine | −− | isoursodeoxycholate | Rikenellaceae_RC9_gut_group | ++ | homocitrulline | Megasphaera | −− | GDF15 | X - 15461 |
| − | AMBP | eicosapentaenoate (EPA; 20:5n3) | −− | isoursodeoxycholate | Prevotella_2 | ++ | TGFA | Megamonas | + | Total Bilirubin | C-glycosyltryptophan |
| − | SULT1A1 | phosphoethanolamine | − | isoursodeoxycholate | Anaeroplasma | ++ | TGFA | Megasphaera | + | LDL Size | 1-palmityl-2-oleoyl-GPC (O-16:0/18:1)* |
| − | phenylpyruvate | GCA-900066225 | + | ITGB2 | X - 21258 | ++ | glucose | Klebsiella | + | High-sensitivity CRP | taurocholate |
| − | IL18 | cysteine s-sulfate | + | Lymphocytes | lactate | ++ | hydroxyasparagine** | DTU089 | + | LDL Size | 1-(1-enyl-oleoyl)-2-docosahexaenoyl-GPE (P-18:1/22:6)* |
| + | BMP6 | 2-arachidonoyl-GPC (20:4)* | + | 1-arachidonoyl-GPE (20:4n6)* | Tyzzerella | ++ | epiandrosterone sulfate | Lachnospiraceae_UCG-008 | − | Arachidonic acid | 1-adrenoyl-GPC (22:4)* |
| + | FGF23 | eicosanedioate (C20-DC) | + | CD6 | 1-palmitoyl-2-oleoyl-GPE (16:0/18:1) | ++ | glucose | Enterobacter | + | CCL19 | Oxalobacter |
| − | N-acetylglutamate | Faecalibacterium | − | Triglycerides | X - 18899 | ++ | Alkaline Phosphatase | CHI3L1 | + | X - 15461 | Allisonella |
| + | FGF23 | 2-aminooctanoate | − | IL7 | X - 18901 | ++ | hydroxyasparagine** | Megasphaera | + | TFF3 | 3-methylglutarylcarnitine (2) |
| − | CD93 | X - 17676 | − | ursodeoxycholate | Rikenellaceae_RC9_gut_group | ++ | CD4 | 1-eicosapentaenoyl-GPE (20:5)* | + | mannitol/sorbitol | Turicibacter |
| Delta age status | |||||||||||
| Female Bio. Younger | Female Bio. Older | Male Bio. Younger | Male Bio. Older | ||||||||
| ++ | X - 12216 | Faecalibacterium | ++ | ACE2 | alpha-ketoglutarate | ++ | CCL19 | mannitol/sorbitol | −− | CHIT1 | X - 12544 |
| −− | cinnamoylglycine | Anaeroplasma | ++ | Hemoglobin A1C | alpha-ketobutyrate | ++ | CD4 | X - 15461 | ++ | Red Blood Cell Distribution Width | taurochenodeoxycholate |
| −− | cinnamoylglycine | Prevotellaceae_UCG-001 | −− | Urea | UBA1819 | −− | SRC | phosphatidylcholine (14:0/14:0, 16:0/12:0) | ++ | Glucose | N-acetylvaline |
| ++ | IL6 | N-acetylglutamine | ++ | ACE2 | xanthine | −− | BOC | Ectoine | ++ | Red Blood Cell Distribution Width | X - 12007 |
| ++ | IL6 | N-acetylglutamine | −− | Bun/Creatinine Ratio | UBA1819 | ++ | hippurate | Alistipes | ++ | Glucose | linoleoyl-linoleoyl-glycerol (18:2/18:2) [1]* |
| ++ | isoursodeoxycholate | Prevotella_2 | ++ | N-stearoyl-sphingosine (d18:1/18:0)* | Enterorhabdus | −− | STK4 | phosphatidylcholine (14:0/14:0, 16:0/12:0) | ++ | Glucose | mannose |
| ++ | CCL2 | N-acetylvaline | ++ | Hemoglobin A1C | gluconate | ++ | Red Blood Cell Distribution Width | isobutyrylcarnitine (C4) | ++ | Red Blood Cell Distribution Width | taurocholate |
| −− | IL6 | Agathobacter | −− | alpha-hydroxyisocaproate | Faecalibacterium | −− | MMP7 | X - 11632 | −− | HAVCR1 | 1-ribosyl-imidazoleacetate* |
| ++ | IL6 | N-acetyl-1-methylhistidine* | −− | LPL | sphingomyelin (d18:0/20:0, d16:0/22:0)* | −− | CTSL | X - 13835 | −− | Mean Corpuscular Hemoglobin | CST5 |
| ++ | CCL3 | 6-bromotryptophan | −− | LPL | behenoyl dihydrosphingomyelin (d18:0/22:0)* | −− | SPON2 | Ectoine | −− | CHI3L1 | behenoyl sphingomyelin (d18:1/22:0)* |
For each test group, the ten analyte pairs with the lowest p-values for the interaction term representing the modification of APOE or delta age status on the association between the two analytes are tabulated. ‘+’ and ‘−’ indicate positive and negative interaction terms, respectively, with ‘++’ or ‘--’ indicating significance at pFDR < 0.1 (Supplementary File 3 for full data). Underlining indicates a metabolite associated with the experimental group in the analysis of differential metabolite abundance (with pre-adjusted p < 0.05). Metabolite names ending in “*” indicate compounds not confirmed based on a standard but having high confidence in its identity, while those ending in “**” indicate compounds for which a standard is not available, but for which there is reasonable confidence in its identity or the information provided.