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. 2025 Mar 24;69(3):231–240. doi: 10.1159/000544973

Table 5.

Number of cases with the cytomorphological features in cytological specimens compared to cell block samples

Cytomorphological feature FN AUS (n = 17), n FN SUMP (n = 5), n TP BN (n = 21), n Total (n = 43), n (%)
cytol. CB p value cytol. CB p value cytol. CB p value cytol. CB p value
Background Necrosis 0 1 1.000 2 0 0.444 0 0 ND 2 (4.7) 1 (2.3) 1.000
Haemorrhage 5 9 0.296 0 1 1.000 9 9 1.000 14 (32.6) 19 (44.2) 0.375
Cystic haemorrhage 1 1 1.000 1 0 1.000 4 1 0.343 6 (14.0) 2 (4.7) 0.265
Inflammatory background 0 0 ND 0 0 ND 5 2 0.410 5 (11.6) 2 (4.7) 0.433
Lymphohistiocytic aggregates 4 2 0.656 0 0 ND 7 9 0.751 11 (25.6) 11 (25.6) 1.000
Granular cystic debris 1 1 1.000 0 0 ND 0 0 ND 1 (2.3) 1 (2.3) 1.000
Macrophages 11 8 0.491 3 2 1.000 8 4 0.306 22 (51.2) 14 (32.6) 0.125
Lymphocytes 17 13 0.103 5 4 1.000 21 19 0.488 43 (100) 36 (83.7) 0.012
Plasma cells 1 0 1.000 0 0 ND 6 3 0.454 7 (16.3) 3 (7.0) 0.313
Neutrophils 8 6 0.728 3 4 1.000 12 3 0.009 23 (53.5) 13 (30.2) 0.048
Adipocytes 0 1 1.000 0 0 ND 1 0 1.000 1 (2.3) 1 (2.3) 1.000
Fibroblast 1 0 1.000 0 0 ND 0 0 ND 1 (2.3) 0 (0.0) 1.000
Crystals, crystalloids 3 2 1.000 0 0 ND 2 0 0.488 5 (11.6) 2 (4.7) 0.433
Debris 9 10 1.000 3 2 1.000 11 5 0.111 23 (53.5) 17 (39.5) 0.280
Mucinous like 1 0 1.000 0 0 ND 1 0 1.000 2 (4.7) 0 (0.0) 0.494
Keratin 0 2 0.485 0 0 ND 2 0 0.488 2 (4.7) 2 (4.7) 1.000
Architecture Hypocellularity 1 1 1.000 0 0 ND 0 0 ND 1 (2.3) 1 (2.3) 1.000
Cellularity (diffuse hypercellularity) 0 0 ND 1 0 1.000 0 0 ND 1 (2.3) 0 (0.0) 1.000
Large intact fragments 0 0 ND 0 0 ND 1 0 1.000 1 (2.3) 0 (0.0) 1.000
Sheets 4 0 0.103 2 1 1.000 10 1 0.004 16 (37.2) 2 (4.7) <0.001
Honeycomb sheets 0 0 ND 1 0 1.000 0 0 ND 1 (2.3) 0 (0.0) 1.000
Formation of trabeculae 3 0 0.227 3 0 0.167 7 1 0.045 13 (30.2) 1 (2.3) 0.001
Papillae 2 1 1.000 1 0 1.000 12 20 0.009 15 (34.9) 21 (48.8) 0.274
Discohesivity 1 1 1.000 0 0 ND 0 0 ND 1 (2.3) 1 (2.3) 1.000
Single cells 1 1 1.000 0 1 1.000 1 0 1.000 2 (4.7) 2 (4.7) 1.000
Small groups 4 2 0.656 4 0 0.048 12 6 0.118 20 (46.5) 8 (18.6) 0.011
Cell Spindled cells 0 0 ND 0 1 1.000 0 0 ND 0 (0.0) 1 (2.3) 1.000
Oncocytic cells 10 10 1.000 3 3 1.000 18 21 0.232 31 (72.1) 34 (79.1) 0.616
Oncocytoid cells 1 1 1.000 1 1 1.000 0 0 ND 2 (4.7) 2 (4.7) 1.000
Acini 0 2 0.485 0 0 ND 1 0 1.000 1 (2.3) 2 (4.7) 1.000
Cytoplasmic granules 2 1 1.000 0 0 ND 0 0 ND 2 (4.7) 1 (2.3) 1.000
Nuclear Size variability 1 1 1.000 0 0 ND 0 0 ND 1 (2.3) 1 (2.3) 1.000

FN, false negative; TP, true positive; cytol., cytology; CB, cell block; ND, not determined.