FIG. 7.

Impaired DTH reaction in mIκBβ transgenic mice. Changes in ear thickness and histopathologic scores for severity of edema and cellular infiltrates in sensitized transgenic mice were significantly lower than in sensitized controls (top panels). Naive control and transgenic mice were histopathologically unremarkable (left middle and bottom panels). Ear lesions in sensitized controls were characterized by a moderate edema and marked transdermal cellular infiltrate (right middle panel); ear lesions in sensitized transgenic mice were similar in nature but significantly less severe (right bottom panel). Sections were graded for severity of edema and cellular infiltrate without knowledge of treatment group as follows: 0, none; 1, minimal; 2, mild; 3, moderate; and 4, marked. Bar, 100 μm.