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Altered humoral immune response to the T-cell-dependent antigen NP-KLH. Control (C) and transgenic (Tg) mice (three animals per group) were immunized with NP-KLH, and serum samples were collected after 7, 14, and 21 days. Levels of NP-specific IgG1 were determined by ELISA. The levels of NP-specific antibodies in unchallenged controls were below the limits of detection.
