TABLE 1.
Pertinent phenotypes of cell lines used in these experiments
Cell line | Derivation | Phenotype | Reference |
---|---|---|---|
Hepa-1 | C57BL/6 mouse hepatoma | AHR+ ARNT+ CYP1A1+; wild-type | 3 |
c37 | Hepa-1 | AHR+ ARNT+ CYP1A1−; two nonsense mutations in the Cyp1a1 gene | 24, 33 |
CX4 | c37 | AHR+ ARNT+ CYP1A1+; c37 stable transfectant of plasmid-encoded wild-type mouse CYP1A1 cDNA | 56, 57 |
CH3.3 | c37 | AHR+ ARNT+ CYP1A1− CYP1A2+; c37 stable transfectant of plasmidencoded wild-type human CYP1A2 cDNA | 56, 57 |
CPr | c37 | AHR+ ARNT+ CYP1A1−; c37 stable transfectant of a plasmid with enhancerless mouse CYP1A1 cDNA | 56, 57 |
CV-1 | African green monkey kidney | AHR− ARNT+a CYP1A1− | 31 |
ARNT+ phenotype is weakly expressed in CV-1 cells.