Table 3.
Trials assessing MMAE as adjunct to surgery (N = 16)
| Trial Name | Country | Size | End date | Status | Population | Industry funded | Agent | Primary outcome | Follow-up |
|---|---|---|---|---|---|---|---|---|---|
| DAMMET | USA | 40 | 01–24 | Completed | None | No | Not stated | Repeat surgery | 3 months |
| STORMM | Switzerland | 180 | 01–27 | Not yet recruiting | Symptoms or failed conservative | No | Not stated | Symptomatic recurrence, repeat surgery, or on scan | 6 months |
| OTEMACS | France | 440 | 12–22 | Unknown | Symptoms + MRS 3 or less | No | Onyx™ | Repeat surgery or radiological | 3 months |
| MEMBRANE | Germany | 376 | 05–25 | Active, not recruiting | MRS 3 or less | Yes | TRUFIILL n-BCA® (Cyanoacrilates) | Resolution | 6 months |
| LEADH | France | 550 | 09–26 | Recruiting | None | No | Cyanoacrilates | Repeat surgery or radiological | 6 months |
| ChiCTR2000039359 | China | 480 | 11–21 | Not yet recruiting | “Requiring surgery” | No | Not stated | Repeat surgery or radiological | Not stated |
| METRICS | China | 546 | 12–24 | Not yet recruiting | One risk factor for recurrence | No | Not stated | Repeat surgery or radiological or new disability from neurological cause | 6 months |
| NCT04065113 | USA | 600 | 01–25 | Unknown | Symptoms | No | PVA particles | Repeat surgery | 3 months |
| ELIMINATE | Netherlands | 170 | 10–25 | Recruiting | Symptoms | No | PVA particles | Repeat surgery | 6 Months |
| EMMA-Can 1 | Canada | 200 | 01–26 | Recruiting | Symptoms and MRS 2 or less | No | PVA particles | Radiological | 3 Months |
| MEMBRANE | Germany | 154 | 10–25 | Recruiting | None | No | PVA particles or Onyx™ | Repeat surgery or radiological | 3 Months |
| ENCLOSURE | Spain | 280 | 12–23 | Unknown | > 10 mm or symptoms | No | Onyx™, SQUID®, Phil™, Libro® | Radiological | 6 Months |
| EMPROTECT | France | 342 | 12–22 | Unknown | Recurrence or high risk of | No | Not stated | Repeat surgery or radiological | 6 Months |
| ChiCTR1800018714 | China | 60 | 12–20 | Recruiting | Symptoms | No | Not stated | Repeat surgery | Not stated |
| NCT04272996 | USA | 60 | 06–24 | Recruiting | Symptoms and MRS 4 or less | No | Not stated | Radiological | 3 Months |
| U1111-1254–3825 | Australia | 72 | 04–24 | Recruiting | Symptoms | Yes | Not stated | Radiological and new symptoms requiring surgery | 6 Months |