Table 2.
Diagnostic Performance of the Sarcopenia, Sarcopenia Components and Functional Performance on Onset of Chronic Kidney Disease
| Parameter | Model Diagnostic Performance |
Inter-Model Comparison on Discrimination Performance |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| AUC (95% CI) | Cutoff | Sensitivity | Specificity | PPV | NPV | P-AUC | IDI (95% CI) | P-IDI | NRI (95% CI) | P-NRI | |
| Men (n = 3,966) | |||||||||||
| Left HGS, kg | 0.529 (0.502-0.557) | 35.2 | 0.459 | 0.595 | 0.141 | 0.884 | 0.28 | −0.012 (0.017 to −0.007) | <0.001 | −0.086 (0.119 to −0.053) | <0.001 |
| Right HGS, kg | 0.532 (0.505-0.559) | 30.9 | 0.226 | 0.832 | 0.163 | 0.881 | 0.33 | −0.012 (0.017 to −0.007) | <0.001 | −0.086 (0.119 to −0.053) | <0.001 |
| HGS, low | 0.520 (0.502-0.538) | Positive | 0.190 | 0.850 | 0.154 | 0.879 | <0.001 | −0.012 (0.017 to −0.007) | <0.001 | −0.086 (0.119 to −0.053) | <0.001 |
| Chair stand test, s | 0.535 (0.507-0.563) | 10.4 | 0.449 | 0.649 | 0.156 | 0.891 | 0.48 | −0.012 (0.013 to −0.008) | <0.001 | −0.085 (0.118 to −0.052) | <0.001 |
| Chair stand, low | 0.527 (0.506-0.548) | Positive | 0.269 | 0.785 | 0.153 | 0.881 | <0.001 | −0.011 (0.016 to −0.006) | <0.001 | −0.086 (0.119 to −0.053) | <0.001 |
| ASMI, kg/m2 | 0.505 (0.478-0.532) | 7.3 | 0.369 | 0.675 | 0.135 | 0.878 | 0.01 | −0.013 (0.018 to −0.008) | <0.001 | −0.086 (0.119 to −0.053) | <0.001 |
| ASMI, low | 0.501 (0.483-0.519) | Positive | 0.174 | 0.828 | 0.127 | 0.874 | <0.001 | −0.013 (0.018 to −0.008) | <0.001 | −0.086 (0.119 to −0.053) | <0.001 |
| Sarcopenia, grade | 0.515 (0.500-0.529) | Positive | 0.116 | 0.913 | 0.162 | 0.877 | 0.006 | −0.012 (0.017 to −0.007) | <0.001 | −0.086 (0.119 to −0.053) | <0.001 |
| Sarcopenia, yes | 0.514 (0.500-0.529) | Positive | 0.116 | 0.913 | 0.162 | 0.877 | 0.006 | −0.012 (0.017 to −0.007) | <0.001 | −0.086 (0.119 to −0.053) | <0.001 |
| ADL, binary | 0.546 (0.528-0.564) | Positive | 0.188 | 0.905 | 0.222 | 0.885 | 0.92 | −0.003 (0.006 to −0.001) | 0.006 | 0.002 (0.016 to 0.019) | 0.84 |
| ADL score | 0.546 (0.528-0.564) | 1 | 0.188 | 0.905 | 0.222 | 0.885 | Ref | Ref | Ref | Ref | Ref |
| Women (n = 4,681) | |||||||||||
| Left HGS, kg | 0.523 (0.495-0.552) | 16.1 | 0.141 | 0.899 | 0.127 | 0.910 | 0.066 | −0.013 (−0.017 to −0.008) | <0.001 | −0.070 (−0.100 to −0.040) | <0.001 |
| Right HGS, kg | 0.538 (0.510-0.567) | 30.9 | 0.806 | 0.270 | 0.103 | 0.931 | 0.20 | −0.012 (−0.016 to −0.008) | <0.001 | −0.070 (−0.100 to −0.040) | <0.001 |
| HGS, low | 0.517 (0.498-0.536) | Positive | 0.189 | 0.845 | 0.112 | 0.910 | <0.001 | −0.013 (−0.013 to −0.009) | <0.001 | −0.070 (−0.100 to −0.040) | <0.001 |
| Chair stand test, s | 0.534 (0.505-0.563) | 12.8 | 0.317 | 0.760 | 0.120 | 0.915 | 0.15 | −0.013 (−0.017 to −0.008) | <0.001 | −0.066 (−0.097 to −0.036) | <0.001 |
| Chair stand, low | 0.529 (0.505-0.552) | Positive | 0.374 | 0.684 | 0.109 | 0.913 | <0.001 | −0.013 (−0.017 to −0.008) | <0.001 | −0.070 (−0.100 to −0.040) | <0.001 |
| ASMI, kg/m2 | 0.529 (0.505-0.552) | 6.3 | 0.403 | 0.647 | 0.106 | 0.913 | 0.038 | −0.014 (−0.018 to −0.009) | <0.001 | −0.070 (−0.100 to −0.040) | <0.001 |
| ASMI, low | 0.507 (0.487-0.527) | Positive | 0.788 | 0.227 | 0.095 | 0.912 | 0.001 | −0.014 (−0.018 to −0.009) | <0.001 | −0.070 (−0.100 to −0.040) | <0.001 |
| Sarcopenia, grade | 0.507 (0.487-0.527) | Positive | 0.134 | 0.890 | 0.112 | 0.909 | <0.001 | −0.013 (−0.018 to, −0.009) | <0.001 | −0.070 (−0.100 to −0.040) | <0.001 |
| Sarcopenia, yes | 0.512 (0.496-0.529) | Positive | 0.134 | 0.890 | 0.112 | 0.909 | <0.001 | −0.013 (−0.018 to −0.009) | <0.001 | −0.007 (−0.100 to −0.040) | <0.001 |
| ADL, binary | 0.558 (0.537-0.579) | Positive | 0.255 | 0.862 | 0.160 | 0.918 | 0.23 | −0.005 (−0.007 to −0.003) | <0.001 | −0.007 (−0.100 to −0.040) | <0.001 |
| ADL score | 0.559 (0.538-0.581) | 1 | 0.255 | 0.862 | 0.160 | 0.918 | Ref | Ref | Ref | Ref | Ref |
Abbreviations: ADL, activities of daily living score; ASMI, appendicular skeletal muscle index; AUC, area under the curve; CI, confidence interval; HGS, handgrip strength; IDI, integrated discrimination improvement; NRI, net reclassification improvement; NPV, negative predictive value; PPV, positive predictive value.