Table 4.
Multivariable Models of the Relationship Between Functional Performance and Chronic Kidney Disease
| Models | Overall Populationa, OR (95% CI) |
Sensitivity Analysisa, OR (95% CI) |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| No./events | Model 1b | Model 2c | Model 3d | Model 4e | No./events | Model 5f | No./events | Model 6g | |
| ADL, continuous | 8,647/940 | 1.293 (1.199-1.391) | 1.300 (1.203-1.401) | 1.280 (1.181-1.383) | 1.258 (1.130-1.393) | 8,647/138 | 1.298 (1.021-1.587) | 8,647/510 | 1.267 (1.107-1.436) |
| ADL, ≥1 versus 0 | 8,647/940 | 2.078 (1.751-2.457) | 2.125 (1.783-2.525) | 2.051 (1.710-2.452) | 1.841 (1.446-2.329) | 8,647/138 | 1.773 (0.992-3.020) | 8,647/510 | 1.971 (1.448-2.654) |
| ADL, severityh | |||||||||
| 0 | 7524/734 | Ref = 1 | Ref = 1 | Ref = 1 | Ref = 1 | 7524/107 | Ref = 1 | 7524/389 | Ref = 1 |
| 1 versus 0 | 690/120 | 1.948 (1.571-2.397) | 1.987 (1.599-2.452) | 1.922 (1.535-2.390) | 1.590 (1.168-2.133) | 690/19 | 1.636 (0.777-3.108) | 690/72 | 1.847 (1.257-2.649) |
| ≥ 2 versus 0 | 433/86 | 2.293 (1.780-2.924) | 2.363 (1.824-3.033) | 2.271 (1.738-2.939) | 2.274 (1.612-3.161) | 433/12 | 2.003 (0.843-4.165) | 433/49 | 2.175 (1.387-3.305) |
Abbreviations: ADL, activities of daily living; CI, confidence interval; OR, odds ratio.
Individuals with missing values of independent variable were excluded from analysis.
Model 1 is the unadjusted crude model.
Model 2 is adjusted for the age at baseline and sex.
Model 3 is adjusted for the age at baseline, sex, marital status, residence, drinking status, smoking status, body mass index, educational level, hypertension, diabetes, heart disease, use of hypertension medications, use of diabetes medications, and use of lipid-lowering medications.
Model 4 is adjusted for all variables in Model 3, plus serum urea nitrogen, serum creatinine, cystatin C, and uric acid.
Model 5 is adjusted for all covariates in Model 4, but only assessed the onset of chronic kidney disease at the first wave of follow-up (baseline in 2011, first wave of follow-up in 2013).
Model 6 is adjusted for all covariates in Model 4, but only assessed the onset of chronic kidney disease at the first 2 waves of follow-up (baseline in 2011, second wave of follow-up in 2013 and 2015).
P for trend: Model 1 < 0.001, Model 2 < 0.001, Model 3 < 0.001, Model 4 < 0.001, Model 5 = 0.039, and Model 6 < 0.001.