Skip to main content
. 2025 May 9;11(6):3114–3125. doi: 10.1021/acsbiomaterials.4c01931

3. A Summarization of Recent Methacrylated SF-Based Approaches in Nerve Tissue Engineering.

Biomaterials Seeded Cells Fabrication Method Construct Type Results
SF, MA Human neuroblastoma cells UV photocross-linking, film casting Scaffold Increased mechanical stiffness, water stability, rigidity (to 480 kPa), contact angle (to 70.8°); cell differentiation and adhesion for 12 days
SF, GMA, GO Mouse neuroblast cells 3D DLP bioprinting Hydrogel Improved hydrogel mechanical, electroconductive (up to 6.5 S/m), neurogenic (expression of neuronal proteins) properties; cell proliferation, viability for 5 days
SF, MA Rat Schwann cells Electrospun fiber films, UV photocross-linking Scaffold Oriented axonal growth, Schwann cell myelination, motor function recovery (using sciatic nerve function index) 12 weeks postop
SF, GMA Rat PC12 cells UV photocross-linking Hydrogel Promoted cell growth, function, and regeneration; inhibited inflammatory reaction and oxidative stress 7 days after spinal cord injury
SF, GMA, LM-AC Rat neural stem cells UV photocross-linking Hydrogel In situ cell adhesion, cell growth, neural regeneration; repair of complete transection spinal cord injury after 7 days
SF, GMA, BP, GA Mouse macrophages, human neuroblastoma cells UV photocross-linking Hydrogel Cell differentiation and proliferation; inhibited inflammation, promoted conductivity (up to 0.4 S/m)