Table 4.

Summary of the Odds Ratio for Disease Progression of Different Predictive Cutoff Values of pRNFL and GCIPL Baseline and Annualized Rate of Change in Thickness

Retinal layer thresholds	Cutoff (μm)	Odds ratio and 95% CI	p Value	I2 test
Cross-sectional predictive cutoff
pRNFL layer
Baseline pRNFL	87–88 μm	3.006 (1.77–5.108)	0.043	68%
GCIPL layer
High vs low baseline thickness	70–77 μm	5.811 (2.554–13.223))	<0.001	0%
Annualized rate of change
aLGCIPL
aLGCIPL	1 μm/y	13.083 (7.278–23.517)	<0.001	54%
aLpRNFL
aLpRNFL	1–1.5 μm/y	6.752 (1.131–40.323)	0.036	90%

Abbreviations: alGCIPL = annualized loss of GCIPL; aLpRNFL = annualized loss of Prnfl; CI = confidence interval; GCIPL = macular ganglion cell/inner plexiform layer; pRNFL = peripapillary retinal nerve fiber layer; μm/y = micrometer per year.