Table 5.

Summary of the Hazard Ratios for Physical Disability Worsening (Specifically EDSS Progression) of Different Predictive Cutoff Values of pRNFL and GCIPL Baseline

Retinal layer thresholds	Cutoff chosen	Hazard ratio and 95% CI	p Value	I2 test	Egger test
Cross-sectional predictive cutoff
pRNFL
High vs low baseline thickness	87–100 μm	2.028 (1.699–2.42)	<0.001	0%	0.016
Baseline pRNFL	87–88 μm	2.258 (1.752–2.909)	<0.001	0%	0.042
GCIPL
High vs low baseline thickness	70–77 μm	2.519 (1.905–3.328)	<0.001	0%	0.76
Baseline GCIPL	77 μm	2.66 (1.815–3.915)	<0.001	15%	0.69
Baseline GCIPL	70 μm	2.493 (1.48–4.19)	0.001	0%	—

Abbreviations: alGCIPL = annualized loss of GCIPL; aLpRNFL = annualized loss of pRNFL; CI = confidence interval; GCIPL = macular ganglion cell/inner plexiform layer; EDSS = Expanded Disability Status Scale; pRNFL = peripapillary retinal nerve fiber layer; μm/y = micrometer per year.