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. 2025 Jun 2;26(11):5349. doi: 10.3390/ijms26115349

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© 2025 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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The mechanism of histone methylation in neuronal cell following nerve injury. (A) Histone methylation regulates the axon regeneration in DRG neuron following nerve injury. (B) Histone methylation regulates the neuron survival and axon degeneration in RGC or OPCs following nerve injury. (C) Histone methylation modulates the cell proliferation, axon guiding and myelin thickness of Schwann cell following nerve injury. (D–H) Histone methylation regulates the function of DRG and dorsal horn neurons in pain following nerve injury. DCA (Dorsal column axotomy); SNA (Sciatic nerve axotomy); TBI (Traumatic brain injury); RGC (Retinal ganglion cell); OPCs (Oligodendrocyte precursor cells); CCI-IoN (Chronic constriction injury of the infraorbital nerve); TG (Trigeminal ganglion).