. 2005 Jul 21;6(1):78. doi: 10.1186/1465-9921-6-78

Table 6.

Studies measuring serum biomarkers in patients with other ILDs

Investigator	Patients Controls	Biomarker / Summary	ROC curve analysis Cut-off values	Specificity – Sensitivity Diagnostic accuracy	Limitations
Ohnishi et al. ⁹²	30	Elevated circulating KL-6 levels in patients with drug induced pneumonitis	No KL-6: 520 U/ml	Sensitivity: 53 – 89%	Small number of patients / Discrepancies with CT features
Kohno et al. ⁹³	15	Circulating antigen KL-6 and LDH for monitoring irradiated patients with lung cancer	No	Not estimated	Small number of patients / Retrospective study / Evaluation of serial measurement not definitive
Goto et al. ⁹⁴	16	Serum levels of KL-6 are useful biomarkers for severe radiation pneumonitis	No	Not estimated	Small number of patients / Retrospective study / Chemotherapy influence
Takahashi et al.⁹⁵	25	Diagnostic significance of SP-A and SP-D in sera from patients with radiation pneumonitis	No	Sp-A: 83 - 85% Sp-D: 83 - 85%	Small number of patients / Chemotherapy influence / No long term follow-up / Non ILD-specific markers
Al-Salmi et al. ⁹⁷	10 10	Elevated serum KL-6 and SP-A and SP-D in pediatric ILDs	No	Not estimated	Small number of patients / Diversity of the diseases studied / Poor correlation with functional and radiological parameters

Abbreviations: BAL: Bronchoalveolar lavage, CBD: Chronic Beryllium Disease CT: Computed Tomography, FLD: Farmer's Lung Disease, ILDs: Interstitial Lung Diseases IPF: Idiopathic Pulmonary Fibrosis, KL-6: Krebs von den Lungen-6, LDH: Lactate Dehydrogenase, ROC: Receiver Operating Characteristic, SP: Surfactant Protein