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[Preprint]. 2025 Jun 6:2025.06.03.656903. [Version 1] doi: 10.1101/2025.06.03.656903

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Figure 1| — A. The lifespan of PolgA^D257A is not rescued by deletion of the Pappa gene. B-C. A homozygous deletion of the Pappa gene leads to decreased weight and increased frailty in male and female PolgA^D257A mice (male n = 8–22/group, female n = 6–13/group). D. Appearance and size distribution of WT and mutant mice (grid size = 1 cm²).