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[Preprint]. 2025 Sep 8:2025.05.30.657115. Originally published 2025 Jun 3. [Version 2] doi: 10.1101/2025.05.30.657115

Figure 6. Minimal gene expression changes in Ptbp1 cKO astrocytes.

Figure 6.

(A) Volcano plot showing DEGs between control and Ptbp1 cKO astrocyte samples. Upregulated genes are highlighted in pink and downregulated genes in green. (B) PCA of TPM values across control, Ptbp1 cKO astrocytes, and in vitro differentiated neuron samples at various differentiation stages (DIV-8, DIV-4, DIV0, DIV1, DIV7, DIV16, DIV21, and DIV28). (C) Spearman’s correlation analysis comparing TPM values between control, Ptbp1 cKO astrocytes, and in vitro differentiated neuron samples (DIV0 and DIV28). (D) PCA of TPM values across control, Ptbp1 cKO astrocytes, and cortical tissue samples at various developmental stages (E10, E11, E12, E13, E14, E15, E16, and P0). (E) Spearman’s correlation analysis comparing TPM values between control, Ptbp1 cKO astrocytes, and cortical tissue samples (E10 and P0).