Table 2.
Mutation rates in clear cell RCC of the most frequently mutated genes in TCGA and renal dysfunction cohorts.
| Cohort | Mutated Gene | Renal Dysfunction | TCGA | P-value |
|---|---|---|---|---|
| Total n (%) | 12 (3.1) | 370 (96.6) | ||
| Most Frequent Mutations in TCGA Cohort | VHL | 8 (66.7) | 170 (45.9) | 0.239 |
| PBRM1 | 3 (25.0) | 152 (41.1) | 0.374 | |
| SETD2 | 0 (0.0) | 45 (12.2) | 0.374 | |
| BAP1 | 0 (0.0) | 41 (11.1) | 0.626 | |
| MTOR | 0 (0.0) | 28 (7.6) | 1.000 | |
| KDM5C | 0 (0.0) | 20 (5.4) | 1.000 | |
| KMT2C | 1 (8.3) | 18 (4.9) | 0.463 | |
| ATM | 0 (0.0) | 16 (4.3) | 1.000 | |
| Most Frequent Mutations in Renal Dysfunction Cohort | SDHA | 3 (25.0) | 0 (0.0) | <0.001 |
| IRS2 | 3 (25.0) | 1 (0.3) | <0.001 | |
| SPTA1 | 3 (25.0) | 8 (2.2) | 0.003 | |
| BUB1B | 2 (16.7) | 4 (1.1) | 0.013 | |
| FAT1 | 2 (16.7) | 11 (3.0) | 0.058 | |
| NCOA2 | 2 (16.7) | 3 (0.8) | 0.009 |