Table 3.

Mutation rates in papillary RCC of the most frequently mutated genes in TCGA and renal dysfunction cohorts.

Cohort	Mutated Gene	Renal Dysfunction	TCGA	P-value
	Total n (%)	12 (4.1)	278 (95.9)
Most Frequent Mutations in TCGA Cohort	MET	1 (8.3)	20 (7.2)	1.000
	KMT2C	0 (0.0)	19 (6.8)	0.472
	KMT2D	1 (8.3)	17 (6.1)	1.000
	FAT1	1 (8.3)	16 (5.8)	1.000
	SETD2	0 (0.0)	15 (5.4)	0.644
	BAP1	0 (0.0)	13 (4.7)	0.665
	ARID1A	0 (0.0)	13 (4.7)	0.665
Most Frequent Mutations in Renal Dysfunction Cohort	BRD4	3 (25.0)	4 (1.4)	0.002
	CHEK2	3 (25.0)	2 (0.7)	0.001
	LRP1B	2 (16.7)	8 (2.9)	0.059
	BRCA2	2 (16.7)	6 (2.2)	0.038
	CSF3R	2 (16.7)	2 (0.7)	0.009
	FAT3	2 (16.7)	3 (1.1)	0.015
	HNF1A	2 (16.7)	3 (1.1)	0.015
	KMT2A	2 (16.7)	6 (2.2)	0.038
	MAGI2	2 (16.7)	5 (1.8)	0.029
	MST1R	2 (16.7)	2 (0.7)	0.009
	PREX2	2 (16.7)	2 (0.7)	0.009
	PRKDC	2 (16.7)	8 (2.9)	0.059
	RARA	2 (16.7)	0 (0.0)	0.002
	RPTOR	2 (16.7)	1 (0.4)	0.005
	SAMD9	2 (16.7)	4 (1.4)	0.022
	TRAF7	2 (16.7)	0 (0.0)	0.002
	U2AF1	2 (16.7)	0 (0.0)	0.002
	XPC	2 (16.7)	0 (0.0)	0.002
	ZNF750	2 (16.7)	0 (0.0)	0.002