Table 2.
Characteristics and outcomes of participants categorized according to PLR tertiles.
| Variables | PLR T1 (n=333) | PLR T2 (n=333) | PLR T3 (n=336) | p-value |
|---|---|---|---|---|
| PLR | 48.91 (36.99, 57.82) | 91.80 (80.75, 109.02) | 232.74 (167.94, 333.86) | <0.001 |
| Personal characteristics | ||||
| Age (years) | 71.68 (62.69,78.74) | 71.24 (63.97,78.65) | 77.48 (67.21,85.11) | <0.001 |
| Gender (%) | 0.251 | |||
| Female | 152 (45.65) | 161 (48.35) | 175 (52.08) | |
| Male | 181 (54.35) | 172 (51.65) | 161 (47.92) | |
| Scores | ||||
| OASIS | 32.00 (26.00,37.00) | 32.00 (26.00,37.00) | 33.00 (27.00,39.00) | 0.133 |
| GCS | 15.00 (14.00,15.00) | 15.00 (14.00,15.00) | 15.00 (14.00,15.00) | 0.584 |
| CCI | 4.00 (3.00,6.00) | 5.00 (3.00,7.00) | 6.00 (5.00,8.00) | <0.001 |
| Comorbidities | ||||
| Respiratory failure (%) | <0.001 | |||
| No | 285 (85.59) | 254 (76.28) | 242 (72.02) | |
| Yes | 48 (14.41) | 79 (23.72) | 94 (27.98) | |
| Diabetes (%) | 0.232 | |||
| No | 238 (71.47) | 224 (67.27) | 220 (65.48) | |
| Yes | 95 (28.53) | 109 (32.73) | 116 (34.52) | |
| Hypertension (%) | 0.591 | |||
| No | 330 (99.10) | 329 (98.80) | 330 (98.21) | |
| Yes | 3 (0.90) | 4 (1.20) | 6 (1.79) | |
| Renal disease (%) | <0.001 | |||
| No | 270 (81.08) | 239 (71.77) | 207 (61.61) | |
| Yes | 63 (18.92) | 94 (28.23) | 129 (38.39) | |
| Sepsis (%) | <0.001 | |||
| No | 320 (96.10) | 297 (89.19) | 247 (73.51) | |
| Yes | 13 (3.90) | 36 (10.81) | 89 (26.49) | |
| Paraplegia (%) | 0.962 | |||
| No | 324 (97.30) | 325 (97.60) | 327 (97.32) | |
| Yes | 9 (2.70) | 8 (2.40) | 9 (2.68) | |
| Laboratory tests | ||||
| Lymphocytes (109/L) | 2.63 (2.17,3.51) | 1.66 (1.34,2.05) | 0.81 (0.57,1.08) | <0.001 |
| Monocytes (109/L) | 0.56 (0.35,0.88) | 0.56 (0.33,0.86) | 0.70 (0.40,1.07) | 0.008 |
| Neutrophils (109/L) | 10.49 (7.98,14.28) | 8.89 (6.49,12.93) | 9.49 (6.69,13.80) | <0.001 |
| Platelets (109/L) | 125.00 (102.00,153.00) | 157.00 (127.00,186.33) | 193.72 (155.75,242.25) | <0.001 |
| NM | 5.41 (2.95,10.40) | 4.76 (2.37,9.04) | 6.50 (3.18,12.71) | <0.001 |
| NP | 1302.14 (892.70,1936.40) | 1341.90 (904.20,2107.28) | 1867.86 (1141.35,2995.47) | <0.001 |
| MP | 66.40 (38.16,114.70) | 80.85 (44.67,143.28) | 144.23 (68.81,223.14) | <0.001 |
| NLR | 3.75 (2.78,5.10) | 5.71 (3.80,7.77) | 11.49 (7.96,20.07) | <0.001 |
| MLR | 0.21 (0.13,0.31) | 0.35 (0.19,0.51) | 0.84 (0.46,1.41) | <0.001 |
| SII | 482.66 (336.37,675.60) | 821.86 (611.51,1198.62) | 2241.60 (1345.33,3987.76) | <0.001 |
| SIRI | 2.10 (1.14,3.77) | 2.81 (1.45,5.91) | 7.61 (3.44,16.17) | <0.001 |
| AIRI | 256.00 (128.19,477.01) | 444.15 (237.56,894.27) | 1479.03 (642.50,3370.15) | <0.001 |
| Outcomes | ||||
| ICU LOS (days) | 2.51 (1.40,4.87) | 2.31 (1.33,4.33) | 2.59 (1.33,5.16) | 0.201 |
| 30‐day ICU mortality (%) | <0.001 | |||
| Alive | 329 (98.80) | 324 (97.30) | 287 (85.42) | |
| Death | 4 (1.20) | 9 (2.70) | 49 (14.58) | |
Medians and interquartile ranges (25th and 75th percentiles) were calculated for continuous variables and frequencies and percentages for categorical variables. The Wilcoxon rank sum test was used to compare group differences for continuous variables and Chiiablesss tests for categorical variables.
AIRI, aggregate index of systemic inflammation response; CCI, charlson comorbidity index; GCS, glasgow coma scale; ICU, intensive care unit; LOS, length of stay; MLR, monocyte-to-lymphocyte ratio; MP, monocyte × platelet; NLR, neutrophil-to-lymphocyte ratio; NM, neutrophil × monocyte; NP, neutrophil × platelet; OASIS, oxford acute severity of illness score; PLR, platelet-to-lymphocyte ratio; T, tertile; SII, systemic immune-inflammation index; SIRI, systemic inflammation response index.