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. 2025 May 29;16:1610967. doi: 10.3389/fimmu.2025.1610967

Table 3.

Cox proportional hazard ratios for 30-day all-cause mortality in rheumatic heart disease patients.

Categories Model 1 Model 2 Model 3 Model 4
HR (95%CI) p-value HR (95%CI) p-value HR (95%CI) p-value HR (95%CI) p-value
30‐day all-cause mortality
(Continuous variable)
2.59 (2.05,3.27) <0.001 2.39 (1.87,3.07) <0.001 2.60 (1.97,3.43) <0.001 2.53 (1.87,3.42) <0.001
PLR tertile
 T1 Ref Ref Ref Ref
 T2 2.72 (1.02, 8.73) 0.047 2.89 (1.05, 9.41) 0.043 2.79 (1.05, 9.16) 0.044 2.60 (1.01, 8.62) 0.049
 T3 12.69 (4.58,35.18) <0.001 11.79 (4.24,32.78) <0.001 12.86 (4.54,36.41) <0.001 11.85 (3.98,35.24) <0.001
HR for trend 5.18 (3.07,8.76) 4.73 (2.80,8.00) 5.15 (2.99,8.87) 4.97 (2.76, 8.93)
p-value for trend <0.001 <0.001 <0.001 <0.001

Model 1: unadjusted.

Model 2: adjusted for age, gender.

Model 3: adjusted for age, gender, OASIS, GCS, CCI.

Model 4: adjusted for age, gender, OASIS, GCS, CCI, respiratory failure, diabetes, hypertension, renal disease, sepsis, paraplegia.

AIRI, aggregate index of systemic inflammation response; CCI, charlson comorbidity index; CI, confidence Interval; GCS, glasgow coma scale; HR, hazard ratio; ICU, intensive care unit; LOS, length of stay; MLR, monocyte-to-lymphocyte ratio; MP, monocyte × platelet; NLR, neutrophil-to-lymphocyte ratio; NM, neutrophil × monocyte; NP, neutrophil × platelet; OASIS, oxford acute severity of illness score; PLR, platelet-to-lymphocyte ratio; T, tertile; Ref, reference; SII, systemic immune-inflammation index; SIRI, systemic inflammation response index.