Table 1.
Conceptual mapping of the shortlisted PRO measures to the symptom Burden domain of the ePRO conceptual framework.
| Sub-domain | FACT (BMT) | MDASI-CAR | QoL-BMT | SBQ |
|---|---|---|---|---|
| Neurological symptoms (n = 17) | 2 | 6 | 2 | 8 |
| Skin and hair-related symptoms (n = 8) | 0 | 0 | 0 | 4 |
| Ear, nose and throat (n = 10) | 1 | 1 | 3 | 5 |
| Clinical signs (n = 9) | 1 | 4 | 1 | 6 |
| Cardiopulmonary (n = 4) | 1 | 1 | 1 | 1 |
| Psychological (n = 8) | 1 | 2 | 4 | 3 |
| Gastrointestinal (n = 6) | 1 | 3 | 2 | 6 |
| Fever-related symptoms (n = 3) | 0 | 1 | 0 | 3 |
| Infection (n = 5) | 1 | 0 | 0 | 1 |
| Sleep (n = 5) | 2 | 2 | 1 | 3 |
| Musculoskeletal (n = 4) | 0 | 0 | 0 | 3 |
| Sexual functioning (n = 3) | 1 | 1 | 2 | 2 |
| Fatigue (n = 3) | 1 | 1 | 1 | 1 |
| Vision/eye-related symptoms (n = 3) | 1 | 0 | 1 | 2 |
| Interference (n = 7) | 5 | 6 | 6 | 6 |
| Total symptom concepts (N = 95) | 18 | 28 | 24 | 54 |
| Sub-domains represented (15/15) (%) | 12 (80%) | 11 (73%) | 11 (73%) | 15 (100%) |
FACT (BMT), Functional Assessment of Cancer Therapy–Bone Marrow Transplant; MDASI-CAR, MD Anderson Symptom Inventory CAR module; QoL-BMT, Quality of Life Bone Marrow Transplant Survivors; SBQ Symptom Burden Questionnaire.