Figure 3.

Scatterplot of t₂ (the coalescence time of all copies of A) and j_o (the number of nonrecombinants) generated in 1,000 replicate forward simulations of a neutral allele that was in one copy t₁ generations in the past and was found at t=0 with a frequency between 0.027 and 0.037 (i.e., x=0.032±0.005, which was chosen to match the frequency of N370S at GBA, 0.032). In each replicate, the allele age (t₁) was chosen randomly from a probability distribution on t in which Pr(t) is proportional to N(t), where N(t) is based on table 1 with N₀=600 and N₁=3,000. Parameters for A and the linked marker are the same as for N370S at GBA: i=268, j_o=163, p_N=0.205, and θ=0.007 (cf. table 2).