Table 2.
Association between XRCC1 Arg399Gln and XPD Lys751Gln genotypes either singly or in combinations to development of lung cancer
| Cases/control | OR (95% CI)a | P-value | |
|---|---|---|---|
| Genotype | |||
| XRCC1 399 GG | 78/102 | Reference | |
| XRCC1 399 GA | 86/80 | 1.4 (0.920–2.148) | 0.11 |
| XRCC1 399 AA | 47/29 | 2.1 (1.224–3.669) | 0.007 |
| XPD 751 AA | 109/139 | Reference | |
| XPD 751 AC | 89/61 | 1.8 (1.233–2.807) | 0.003 |
| XPD 751 CC | 13/11 | 1.5 (0.650–3.495) | 0.33 |
| Genotype combinations | |||
| XRCC1 399 GG/XPD 751 AA | 40/68 | Reference | |
| XRCC1 399 GG/XPD 751 AC + CC | 38/34 | 1.9 (1.037–3.481) | 0.03 |
| XRCC1 399 GA + AA/XPD 751 AA | 71/71 | 1.7 (1.020–2.833) | 0.04 |
| XRCC1 399 GA + AA/XPD 751 AC + CC | 62/38 | 2.7 (1.582–4.864) | 0.01 |
aOdds ratio adjusted for age, gender and smoking