Table 3.
The levels of fucosyltransferase activities in human gastric carcinoma
| Case | Tissue specimen | Fucosyltransferase activity: incorporation of [14C] Fuc (CPM × 10−3) into the acceptor catalyzed by 1 mg protein of the tissue extract | |||
|---|---|---|---|---|---|
| α1,3-FT activity [2-O-MeGalβ1,4 GlcNAc] | α1,4-FT activity [2-O-MeGalβ1,3 GlcNAc] | α1,2-FT activity [Galβ-O-Bn] | FT VI activity [GlcNAc β1,4 GlcNAcβ-O-Bn] | ||
| 51 | NS7323 | 166.4 | 18.4 | 19.9 | 0.8 |
| GC7323 | 655.0 ↑(3.9) | 671.6 ↑(36.5) | 131.9 ↑(6.6) | 159.6 ↑(199.5) | |
| 2 | NS7741 | 449.6 | 68.3 | 127.2 | 3.1 |
| GC7741 | 390.5 ↓(0.9) | 193.9 ↑(2.8) | 111.2 ↓(0.9) | 159.2 ↑(51.4) | |
| 3 | NS7405 | 494.1 | 9.1 | 146.8 | 138.6 |
| GC7405 | 382.6 ↓(0.8) | 2.3 ↓(0.3) | 83.3 ↓(0.6) | 60.6 ↓(0.4) | |
| 4 | NS7570 | 448.8 | 12.3 | 197.2 | 16.7 |
| GC7570 | 180.2 ↓(0.4) | 0 ↓(0) | 16.5 ↓(0.1) | 1.2 ↓(0.1) | |
| 5 | NS9529 | 428.4 | 405.2 | 109.4 | 137.9 |
| GC9529 | 198.2 ↓(0.5) | 211.3 ↓(0.5) | 22.0 ↓(0.2) | 2.7 ↓(0.02) | |
| 6 | NS11681 | 367.8 | 173.6 | 102.7 | 5.4 |
| GC11681 | 278.9 ↓(0.8) | 91.2 ↓(0.5) | 34.4 ↓(0.3) | 3.8 ↓(0.7) | |
| 7 | NS11868 | 533.2 | 268.3 | 76.8 | 42.7 |
| GC11868 | 448.3 ↓(0.8) | 322.6 ↑(1.2) | 49.0 ↓(0.6) | 51.7 ↑(1.2) | |
| 8 | NS11954 | 422.2 | 71.5 | 62.9 | 1.5 |
| GC11954 | 184.0 ↓(0.4) | 201.3 ↑(2.8) | 35.0 ↓(0.6) | 15.8 ↑(0.5) | |
| 9 | NS11847 | 526.3 | 189.5 | 70.9 | 13.6 |
| GC11847 | 352.8 ↓(0.7) | 325.6 ↑(1.7) | 132.1 ↑(1.9) | 121.0 ↑(8.9) | |
| 10 | NS12015 | 483.5 | 417.0 | 108.9 | 227.0 |
| GC12015 | 328.7 ↓(0.7) | 294.5 ↓(0.7) | 62.5 ↓(0.6) | 181.7 ↓(0.8) | |
| 11 | GC7532 | 452.2 | 193.4 | 88.5 | 90.5 |
| 12 | GC11577 | 107.0 | 0.9 | 2.5 | 0.8 |
Values in parentheses indicate the fold of enzyme activity in tumor specimen as compared to that of corresponding normal tissue of the patient
NS Normal stomach, GC gastric carcinoma
↑ Increase, ↓ decrease