Table 1.
Patients’ characteristics
| Relapsed patients | Untreated patients | |
|---|---|---|
| Number of patients | 33 | 11 |
| Age at first diagnosis | ||
| Median (years) | 3.9 | 2.4a |
| Range (years) | 0–12.5 | 0.3–5.8a |
| Age at TCE start | ||
| Median (years) | 6.4 | 2.6 |
| Range (years) | 1.3–21.2 | 1.1–5.8 |
| Observation time | ||
| Median (years) | 2.1 | 1.9 |
| Range (years) | 0.3–3.5 | 1.4–2.7 |
| Sex | ||
| Male | 19 | 6 |
| Female | 14 | 5 |
| INSS stage at first diagnosis | ||
| 1–3 | 9 | 1a |
| 4 | 24 | 10 |
| Extent of disease at TCE start | ||
| Localized | 9 | 0 |
| Metastatic | 24 | 11 |
| Disease pattern at TCE start | ||
| Primary site | 20 | 11 |
| Bone marrow | 17 | 7 |
| Bone | 14 | 7 |
| Liver | 4 | 1 |
| CNS | 2 | 0 |
| Distant lymph nodes | 3 | 2 |
| Pleura | 1 | 1 |
| MYCN status | ||
| Single copy | 24 | 7 |
| Amplified | 9 | 4 |
| Primary treatment | ||
| NB90 without ASCT | 3 | |
| NB97 with ASCT | 17 | |
| NB97 without ASCT | 13 | |
aOne patient had MIBG positive relapse with bone metastasis 10 months after diagnosis of stage 1 neuroblastoma