Table 3.
Disease pattern, response, and outcome of trial patients
| Number | Pre-treatment | Disease pattern at TCE start | Status after two cycles | Best response | Best response confirmed by | Final outcome |
|---|---|---|---|---|---|---|
| 1 | NB97 HR | BM, bone, LN | PD | PD | Clinical | DOD |
| 2 | NB97 HR | PT, BM | PR | PR | CT, BM | DOD |
| 3 | NB97 HR | PT, liver, LN | n.a. | PR | Ultrasound | DOD |
| 4 | NB97 HR | PT | PR | PR | MRI | Relapse |
| 5 | NB97 SR | PT | SD | PR | MRI, MIBG | Progression |
| 6 | NB97 HR | PT, BM, bone | PD | PD | MRI, BM | DOD |
| 7 | NB97 HR | PT, BM, bone | PR | PR | MRI, MIBG | DOD |
| 8 | NB97 HR | PT, BM, bone | PD | PD | MRI, MIBG | DOD |
| 9 | NB90 HR | Bone, pleura, liver | n.a. | SD | MRI, MIBG | SMD |
| 10 | NB97 HR | BM | PR | PR | MIBG, BM | DOD |
| 11 | NB97 SR | PT | VGPR | VGPR | MRI, MIBG | DOD |
| 12 | NB97 SR | PT | PR | PR | MRI | CR2 |
| 13 | NB90 HR | BM, bone | PD | PD | BM | CR2 |
| 14 | NB97 HR | PT, BM, bone, liver | PD | PD | MRI | DOD |
| 15 | NB97 HR | Bone | PR | CR | MRI, MIBG, bone scan | CR2 |
| 16 | NB97 HR | PT, BM | PR | PR | MRI, BM | DOD |
| 17 | NB97 HR | PT | PR | PR | MRI | DOD |
| 18 | NB97 HR | CNS | PR | PR | CCT | DOD |
| 19 | NB97 SR | BM, bone | PR | PR | MRI, BM | Progression |
| 20 | NB97 SR | PT, BM, bone | PD | PD | MRI | CR3 |
| 21 | NB97 HR | BM | n.a. | PR | MIBG, BM | PR |
| 22 | NB97 SR | PT | c.r. | c.r. | MRI | CR3 |
| 23 | NB97 HR | PT, BM, bone | PR | PR | MRI, MIBG, BM | DOD |
| 24 | NB97 HR | BM | PD | PD | MRI, clinical | DOD |
| 25 | NB97 HR | Bone | PR | PR | MIBG, MRI | DOD |
| 26 | NB97 HR | PT | PR | CR | MRI | DOD |
| 27 | NB90 HR + six cycles carboplatin/VP16 | LN | PR | VGPR | MRI | CR3 |
| 28 | NB97 HR | PT | PD | PD | MRI | DOD |
| 29 | NB97 HR | BM, bone | n.a. | PR | MIBG, BM | PR |
| 30 | NB97 HR | BM, CNS | PD | PD | MRI, clinical | Progression |
| 31 | NB97 HR | PT, BM, bone | PD | PD | Clinical | PR |
| 32 | NB97 SR | PT (MIBG negative) | c.r. | c.r. | MRI | CR2 |
| 33 | NB97 HR | PT, liver | PD | PD | MRI | DOD |
| 34 | None | PT, bone | PR | MRI | CR2 | |
| 35 | None | PT, BM, bone | PR | MRI, MIBG, BM | Progression | |
| 36 | None | PT, BM, bone | PR | MRI, MIBG, BM | DOD | |
| 37 | None | PT, LN, pleura | PR | MRI | Progression | |
| 38 | None | PT, BM, bone | SD | Ultrasound, MIBG, BM | DOD | |
| 39 | None | PT, BM | PR | Ultrasound, BM | DOD | |
| 40 | None | PT, bone, LN | PR | MRI, MIBG | CR1 | |
| 41 | None | PT, bone, liver | SD | MRI, BM | CR1 | |
| 42 | None | PT, BM, bone | PR | MRI, MIBG, BM | DOD | |
| 43 | None | PT, bone | PR | MRI | CR1 | |
| 44 | None | PT, BM, bone | PD | MRI, MIBG | CR2 |
PT primary tumor, BM bone marrow, LN distant lymph node, n.a. not assessed, c.r. complete resection, DOD death of disease, SMD secondary malignant disease