Table 2.
Relationship between LOH markers and clinicopathological characteristics
| D14S67 | D14S995 | D14S65 | |||||||
|---|---|---|---|---|---|---|---|---|---|
| LOH (−) (%) n = 23 (57.5) | LOH (+) (%) n = 17 (42.5) | P | LOH (−) (%) n = 17 (44.7) | LOH (+) (%) n = 21 (55.3) | P | LOH (−) (%) n = 28 (62.2) | LOH (+) (%) n = 15 (37.8) | P | |
| Predictors | |||||||||
| Gender | |||||||||
| Male | 18 (78.3) | 14 (82.4) | 1.00d | 14 (82.4) | 17 (81.0) | 1.00d | 24 (85.7) | 14 (82.4) | 1.00d |
| Female | 5 (21.7) | 3 (17.6) | 3 (17.6) | 4 (19.0) | 4 (14.3) | 3 (17.6) | |||
| Age | |||||||||
| Mean ± SD (years) | 64.6 ± 8.9 | 62.2 ± 10.3 | 0.45c | 63.1 ± 8.5 | 65.6 ± 10.5 | 0.46c | 66.7 ± 9.2 | 60.3 ± 8.8 | 0.03 c |
| Smokinge | |||||||||
| Yes | 5 (25.0) | 3 (17.6) | 0.70d | 2 (14.3) | 4 (19.0) | 1.00d | 4 (16.0) | 2 (11.8) | 1.00d |
| No | 15 (75.0) | 14 (82.4) | 12 (85.7) | 17 881.0) | 16 (84.0) | 15 (88.2) | |||
| Alcohol intakee | |||||||||
| Yes | 8 (42.1) | 5 (33.3) | 0.60b | 4 (28.6) | 8 (40.0) | 0.72d | 7 (31.8) | 6 (35.3) | 0.82b |
| No | 11 (57.9) | 10 (66.7) | 10 (71.4) | 12 (60.0) | 15 (68.2) | 11 (64.7) | |||
| TNM stagea, e | |||||||||
| Early stage (I–II) | 5 (23.8) | 5 (29.4) | 0.73d | 4 (28.6) | 4 (19.0) | 0.68d | 6 (23.1) | 5 (31.3) | 0.72d |
| Late stage (III–IV) | 16 (76.2) | 12 (70.6) | 10 (71.4) | 17 (81.0) | 20 (76.9) | 11 (68.7) | |||
| Tumor stagee | |||||||||
| Early T (T1–T2) | 7 (33.3) | 7 (41.2) | 0.62d | 7 (50.0) | 5 (23.8) | 0.15d | 9 (34.6) | 6 (37.5) | 0.85b |
| Late T (T3–T4) | 14 (66.7) | 10 (58.8) | 7 (50.0) | 16 (76.2) | 17 (65.4) | 10 (62.5) | |||
| Nodal stagee | |||||||||
| N (0) | 11 (52.4) | 9 (52.9) | 0.97b | 9 (64.3) | 7 (33.3) | 0.07b | 11 (42.3) | 10 (62.5) | 0.20b |
| N (+) | 10 (47.6) | 8 (47.1) | 5 (35.7) | 14 (66.7) | 15 (57.7) | 6 (37.5) | |||
| Differentiatione | |||||||||
| Well | 4 (16.0) | 7 (43.8) | 0.16d | 4 (28.6) | 8 (38.1) | 0.72d | 8 (32.0) | 6 (37.5) | 0.72b |
| Moderate–poor | 16 (80.0) | 9 (56.3) | 10 (71.4) | 13 (61.9) | 17 (68.0) | 10 (62.5) | |||
| Previous cancere | |||||||||
| With history | 1 (5.6) | 1 (6.3) | 1.00d | 1 (7.7) | 2 (10.0) | 1.00d | 2 (8.7) | 2 (12.5) | 1.00d |
| No history | 17 (94.4) | 15 (93.8) | 12 (92.3) | 18 (90.0) | 21 (91.3) | 14 (87.5) | |||
| Secondary cancer | |||||||||
| With history | 1 (5.6) | 2 (12.5) | 0.59d | 1 (7.7) | 4 (20.0) | 0.62d | 4 (17.4) | 1 (6.3) | 0.63d |
| No history | 17 (94.4) | 14 (87.5) | 12 (92.3) | 16 (80.0) | 19 (82.6) | 15 (93.7) | |||
| Family cancere | |||||||||
| With history | 6 (33.3) | 8 (50.0) | 0.32b | 6 (46.2) | 8 (40.0) | 0.73b | 12 (52.2) | 5 (31.3) | 0.19b |
| No history | 12 (67.7) | 8 (50.0) | 7 (53.8) | 12 (60.0) | 11 (47.8) | 11 (68.7) | |||
| Local recurrencee | |||||||||
| Positive | 3 (23.1) | 6 (30.0) | 1.00d | 3 (23.1) | 6 (30.0) | 1.00d | 6 (26.1) | 5 (31.3) | 0.73d |
| Negative | 10 (76.9) | 14 (70.0) | 10 (76.9) | 14 (70.0) | 17 (73.9) | 11 (68.8) | |||
| Local metastasise | |||||||||
| Positive | 3 (23.1) | 10 (50.0) | 0.12c | 3 (23.1) | 10 (50.0) | 0.12b | 9 (39.1) | 7 (43.8) | 0.77d |
| Negative | 10 (76.9) | 10 (50.0) | 10 (76.9) | 10 (50.0) | 14 (60.9) | 9 (56.3) | |||
| Distant metastasise | |||||||||
| Positive | 2 (15.4) | 7 (35.0) | 0.26d | 2 (15.4) | 7 (35.0) | 0.26d | 8 (34.8) | 2 (12.5) | 0.15d |
| Negative | 11 (84.6) | 13 (65.0) | 11 (84.6) | 13 (65.0) | 15 (65.2) | 14 (87.5) | |||
Bold indicates statistically significant P values
aAccording to the International Union Against Cancer 1997 TNM classification system
bChi-square test
cStudent’s t test
dFisher exact probability test
eCases with unknown history or record of smoking (three), alcohol consumption (three), TNM stage (three), recurrence (six), differentiation (four), previous cancer history (six), and family cancer history (six) were not included in the evaluation