Table 2.

Evolution of host and tumor characteristics in 505 patients over a 25-years period

	Time period
	1981–1990	1991–2000	2001–2006
Number of patients	142	211	152
Age (mean ± SD)	61.8 ± 10.9	61.9 ± 11.6	63.4 ± 12.7
Young (≤40 years old) patients (%)	3.4	3.5	6.6
Male/female ratio	1.95	2.51	1.62
Incidental diagnosis (%)	10.2	40.5	62.7
Tumor size (cm; mean ± SD)	8.5 ± 3.8	7.4 ± 3.5	5.8 ± 2.9
Small (<4 cm) tumors (%)	8.6	17.3	30.6
Tumor spread (%)
Organ-confined	42.1	63.6	68.9
Locally advanced	45.6	27.7	24.3
Metastatic	12.3	8.7	6.8
Histology (%)
Clear cell	87.3	83.9	75.6
Papillary	9.8	5.7	2.0
Chromophobe	0.7	8.5	19.8
Sarcomatoid	2.2	1.9	2.6
Fuhrman’s grade (%)
I/II	62.5	65.7	49.6
III/IV	37.5	34.3	50.4