Table 2.
CD44v6 content in surrounding mucosa and tumor from 105 resectable colorectal carcinomas: correlation with clinicopathological parameters (n.s. not significant)
| Patients and tumors characteristics | No. | CD44v6 surrounding mucosa contenta | CD44v6 tumor contentb | ||||||
|---|---|---|---|---|---|---|---|---|---|
| (ng/mg prot) | (ng/mg prot) | ||||||||
| Median | Mean | Range | P | Median | Mean | Range | P | ||
| Total | 105 | 5.0 | 10.4 | 5.0–230.0 | 19.5 | 37.2 | 2.2–562.9 | ||
| Age (years) | n.s. | n.s. | |||||||
| ≤65 | 23 | 5.0 | 15.6 | 5.0–230.0 | 13.9 | 29.2 | 4.6–137.0 | ||
| >65 | 82 | 5.0 | 8.5 | 5.0–134.7 | 22.4 | 39.5 | 2.2–562.9 | ||
| Sex | |||||||||
| Female | 65 | 5.0 | 8.3 | 5.0–230.0 | 14.2 | 34.1 | 2.2–562.9 | ||
| Male | 40 | 5.0 | 12.8 | 5.0–134.7 | 24.6 | 42.3 | 5.0–196.8 | ||
| Tumor location | n.s. | n.s. | |||||||
| Right colon | 38 | 5.0 | 7.6 | 5.0–230.0 | 12.7 | 23.8 | 2.2–137.0 | ||
| Left colon | 35 | 5.0 | 8.7 | 5.0–134.7 | 15.0 | 41.4 | 5.0–562.9 | ||
| Rectum | 32 | 5.0 | 14.6 | 5.0–230.0 | 29.2 | 47.7 | 5.00–196.8 | ||
| Histological grade | n.s. | n.s. | |||||||
| Well diff. | 26 | 5.0 | 7.6 | 5.0–72.8 | 23.2 | 54.1 | 5.0–562.9 | ||
| Mod. diff. | 72 | 5.0 | 11.2 | 5.0–230.0 | 14.6 | 30.8 | 4.6–196.8 | ||
| Poorly diff. | 7 | 5.0 | 7.8 | 5.0–24.6 | 19.5 | 40.3 | 2.2–173.3 | ||
| Dukes stage | n.s. | n.s. | |||||||
| A | 14 | 5.0 | 5.0 | 5.0–5.0 | 16.4 | 33.2 | 5.0–134.0 | ||
| B | 56 | 5.0 | 12.9 | 5.0–230.0 | 23.9 | 44.9 | 5.0–562.9 | ||
| C | 28 | 5.0 | 7.4 | 5.0–72.8 | 6.9 | 26.7 | 2.2–173.3 | ||
| D | 7 | 5.0 | 7.8 | 5.0–24.6 | 27.8 | 25.8 | 5.0–51.8 | ||
| DNA ploidy status | n.s. | n.s. | |||||||
| Diploid | 35 | 5.0 | 9.1 | 5.0–134.7 | 21.1 | 41.1 | 2.2–562.9 | ||
| Aneuploid | 35 | 5.0 | 11.9 | 5.0–230.0 | 14.9 | 29.5 | 5.0–133.3 | ||
| Unknown | 35 | ||||||||
| S-phase fraction | n.s. | n.s. | |||||||
| Low (≤14%) | 38 | 5.0 | 7.6 | 5.0–72.8 | 18.9 | 40.9 | 2.2–562.9 | ||
| High (>14%) | 37 | 5.0 | 14.6 | 5.0–230.0 | 22.2 | 30.4 | 5.0–133.3 | ||
| Unknown | 30 | ||||||||
aMedian value of CD44v6 content in surrounding mucosa
bMedian value of tumor CD44v6 content