TABLE 3.
Composite Endpoint of Major Adverse Cardiovascular Event for Individuals With and Without Baseline ASCVD
| Composite Endpoint: MACE | ASCVD (n = 10,181) | No ASCVD (n = 6,238) | ||
|---|---|---|---|---|
| 1st-50th percentile | 1,886/5,423 (34.8) | 423/3,618 (11.7) | ||
| 51st-70th percentile | 816/2,086 (39.1) | 144/1,119 (12.9) | ||
| 71st-90th percentile | 749/1,827 (41.0) | 152/1,065 (14.3) | ||
| 91st-100th percentile | 351/845 (41.5) | 94/436 (21.6) | ||
| Unadjusted HR (95% CI) | Adjusteda HR (95% CI) | Unadjusted HR (95% CI) | Adjusteda HR (95% CI) | |
| 1st–50th percentile | Reference | – | Reference | – |
| 51st–70th percentile | 1.18 (1.09–1.28); P < 0.001 | 1.14 (1.05–1.24); P = 0.002 | 1.11 (0.92–1.35); P = 0.265 | 1.09 (0.90–1.32); P = 0.354 |
| 71st–90th percentile | 1.26 (1.15–1.37); P < 0.001 | 1.21 (1.11–1.32); P < 0.001 | 1.24 (1.03–1.49); P = 0.024 | 1.17 (0.97–1.41); P = 0.096 |
| 91st–100th percentile | 1.27 (1.14–1.43); P < 0.001 | 1.26 (1.12–1.41); P < 0.001 | 2.04 (1.63–2.55); P < 0.001 | 1.93 (1.54–2.42); P < 0.001 |
Values are n/N (%) unless otherwise indicated.
a
Adjusted for age, sex, self-reported race/ethnicity, hypertension, chronic kidney disease status, non-Lp(a) hyperlipidemia, diabetes, insulin use (in diabetic individuals), and smoking status.
MACE = major adverse cardiovascular events; other abbreviations as in Table 2.