Table 4.
Clinicopathological correlation of the alterations of CDKN2A, CCND1 and RB1 in head and neck lesions
| Parameter | CDKN2A mutation | P | CDKN2A methylation | P | CDKN2A homo-del | P | D9S942 alterations | P | CCND1 amplification | P | RB1 amplification | P | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| + | − | + | − | + | − | + | − | + | − | + | − | |||||||
| Tobacco+ | 9 | 38 | 0.601 | 8 | 40 | 0.219 | 2 | 46 | 0.739 | 20 | 22 | 0.009 | 8 | 37 | 0.447 | 3 | 36 | 0.860 |
| Tobacco− | 5 | 29 | 9 | 23 | 1 | 32 | 6 | 26 | 3 | 30 | 3 | 29 | ||||||
| Node+ | 3 | 25 | 0.407 | 6 | 21 | 0.879 | 3 | 25 | 0.070 | 10 | 14 | 0.418 | 6 | 20 | 0.107 | 3 | 24 | 0.847 |
| Node− | 11 | 42 | 11 | 42 | 0 | 53 | 16 | 34 | 5 | 47 | 3 | 41 | ||||||
| Dysplasia | 4 | 18 | 0.971 | 4 | 18 | 0.686 | 0 | 22 | 0.062 | 7 | 15 | 0.299 | 1 | 21 | 0.0191 | 0 | 15 | 0.179 |
| Stage I/II | 4 | 22 | 6 | 20 | 0 | 26 | 6 | 17 | 2 | 24 | 2 | 21 | ||||||
| Stage III/IV | 6 | 27 | 7 | 25 | 3 | 30 | 13 | 16 | 8 | 22 | 4 | 29 | ||||||