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. 2025 May 30;17:1611289. doi: 10.3389/fnagi.2025.1611289

TABLE 2.

Association between NPAR and mortality.

Characteristic Model 1 Model 2 Model 3
HR 95% CI P-value HR 95% CI P-value HR 95% CI P-value
All-cause mortality
NPAR (continuous) 1.12 1.08, 1.15 <0.001 1.11 1.07, 1.14 <0.001 1.09 1.05, 1.12 <0.001
NPAR
Q1 Ref Ref Ref Ref Ref Ref
Q2 1.09 0.85, 1.40 0.492 0.99 0.77, 1.27 0.952 0.99 0.77, 1.28 0.934
Q3 1.31 1.02, 1.68 0.032 1.18 0.92, 1.51 0.199 1.09 0.85, 1.41 0.503
Q4 1.95 1.54, 2.48 <0.001 1.72 1.35, 2.18 <0.001 1.69 1.33, 2.16 <0.001
P for trend <0.001 <0.001 <0.001
Cardiovascular mortality
NPAR (continuous) 1.13 1.07, 1.20 <0.001 1.12 1.06, 1.19 <0.001 1.11 1.04, 1.17 <0.001
NPAR
Q1 Ref Ref Ref Ref Ref Ref
Q2 1.08 0.68, 1.72 0.742 0.97 0.61, 1.55 0.904 0.96 0.60, 1.55 0.870
Q3 1.76 1.14, 2.71 0.011 1.57 1.01, 2.43 0.045 1.50 0.95, 2.34 0.079
Q4 2.21 1.43, 3.43 <0.001 1.91 1.23, 2.98 0.004 1.87 1.19, 2.93 0.006
P for trend <0.001 <0.001 <0.001

Model 1: Unadjusted. Model 2: Adjusted for Gender, Age, and Race. Model 3: Adjusted for Gender, Age, Race, Marital status, Education level, PIR, BMI, Smoking, Alcohol use, Diabetes, Hypertension, Medicine use, CVD, ALT, and SCr.