Table 2.
Multivariate survival analysis.
| Variable | Status | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|---|
| HR (95% CI) | P | HR (95% CI) | P | ||
| T category | T2,3 | 1 | 1 | ||
| T4 | 2.19 (1.34–3.58) | 0.002 | 1.97 (1.20–3.23) | 0.007 | |
| N category | N0,1 | 1 | 1 | ||
| N2 | 2.44 (1.57–3.79) | <0.001 | 1.93 (1.22–3.03) | 0.005 | |
| Lymphatic invasion | Absent | 1 | 1 | ||
| Present | 2.72 (1.72–4.31) | <0.001 | 2.42 (1.51–3.88) | <0.001 | |
| TIL group | CD8-low/Ttex-low | 1 | 1 | ||
| CD8-low/Ttex-high | 0.48 (0.28–0.83) | 0.008 | 0.55 (0.32–0.94) | 0.029 | |
| CD8-high | 0.16 (0.04-0.66) | 0.011 | 0.16 (0.04–0.66) | 0.011 | |
| Venous invasion | Absent | 1 | |||
| Present | 1.92 (1.09–3.36) | 0.023 | ns | ||
| Perineural invasion | Absent | 1 | |||
| Present | 2.08 (1.34–3.24) | 0.001 | ns | ||
| TMB | Low | 1 | |||
| High | 0.17 (0.04-0.69) | 0.014 | ns | ||
| MSI status | MSS | 1 | |||
| MSI | 0.84 (0.34-2.08) | 0.707 | ns | ||
CI, confidence interval; HR, hazard ratio; TIL, tumor-infiltrating lymphocyte, Ttex, terminally exhausted CD8+ T cells; TMB, tumor mutational burden; MSI, microsatellite instability; MSS, microsatellite stable; ns, not significant.