TABLE 3.

Sensitivity analysis comparing the Area Under the Curve (AUC) values for each neuropathological model compared to models incorporating (a) age only; and (b) age and APOE e4 status only

	AUC full model (95% CI)	AUC age only (95% CI)	AUC Age + APOE e4 status (95% CI)
Neurodegenerative pathologies
NIA-Reagan	0.67 (0.63 to 0.71)	0.57 (0.52 to 0.61)	0.66 (0.62 to 0.71)
NP	0.71 (0.68 to 0.75)	0.65 (0.61 to 0.69)	0.71 (0.67 to 0.74)
NFT	0.68 (0.64 to 0.72)	0.63 (0.59 to 0.67)	0.67 (0.63 to 0.71)
Vascular pathologies
MVL	0.63 (0.59 to 0.67)	0.52 (0.48 to 0.57)	0.55 (0.51 to 0.59)
LI	0.62 (0.58 to 0.66)	0.59 (0.55 to 0.62)	0.58 (0.54 to 0.62)
Mixed dementia
AD and vascular	0.72 (0.66 to 0.77)	0.63 (0.56 to 0.70)	0.70 (0.65 to 0.76)

Abbreviations: 95% CI, 95% confidence interval; AD, Alzheimer’s disease; AUC, area under the curve; LI, lacunar infarcts; MVL, micro-vascular lesions; NIA-Reagan, National Institutes of Aging Reagan criteria for AD at autopsy; NFT, neocortical neurofibrillary tangles; NP, neocortical neurotic plaques.

Note: Bold text indicates where there are significant differences between the full model and partial models (e.g., models including age alone or age + APOE e4 status).