Figure 3.

Actual mean SF-36 domain scores and LSM changes from baseline in PCS and MCS scores and SF-6D health utility index at (A) Week 12 and Week 52 in ELEVATE UC 52 and (B) Week 12 in ELEVATE UC 12. The SF-36 consists of 36 questions measuring 8 health domains which are scored from 0 (worst possible) to 100 (best possible). PCS and MCS measures were calculated using norm-based scoring. The SF-6D health utility index comprises 7 out of the 8 SF-36 domains (scored from 0.0 [worst measured health state] to 1.0 [best measured health state]). Estimates for PCS, MCS, and SF-6D are from mixed-effect model with repeated measures (ELEVATE UC 52) and an analysis of covariance model (ELEVATE UC 12) for change from baseline with a covariate for baseline score, and factors for naive-to-biologic/JAKi therapy at study entry (Yes/No), baseline corticosteroid use (Yes/No), baseline disease activity (MMS 4-6 or 7-9), and treatment. Covariates for visit and treatment-by-visit interaction were also included in the mixed-effect model with repeated measures. Abbreviations: JAKi, Janus kinase inhibitor; QD, once daily; SF-36, 36-Item Short Form Survey; SF-6D, Short-Form Six-Dimension; LSM, least squares mean; MCS, mental component summary; MMS, modified Mayo score; PCS, physical component summary; UC, ulcerative colitis.