Figure 4.

LSM changes from baseline and LSM treatment differences in WPAI:UC domain scores at (A) Week 12 and Week 52 in ELEVATE UC 52 and (B) Week 12 in ELEVATE UC 12. Bracketed data labels are n/N. The WPAI:UC consists of 6 questions about the effect of UC on 4 domains, each expressed as percentages (0%-100%) of impairment, with lower values indicating less impairment due to disease-specific health problems. Estimates are from a mixed-effect model with repeated measures (ELEVATE UC 52) and an analysis of covariance model (ELEVATE UC 12) with repeated measures model for change from baseline with a covariate for baseline score, and factors for naive-to-biologic/JAKi therapy at study entry (Yes/No), baseline corticosteroid use (Yes/No), baseline disease activity (MMS 4-6 or 7-9), and treatment. Covariates for visit and treatment-by-visit interaction were also included in the mixed-effect model with repeated measures. Abbreviations: Δ, LSM difference between treatments; LSM, least squares mean; n, number of patients; N, number of patients in the full analysis set; QD, once daily; WPAI:UC, Work Productivity and Activity Impairment Questionnaire: Ulcerative Colitis.