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. 2025 May 17;32:101878. doi: 10.1016/j.mtbio.2025.101878

Fig. 3.

Fig. 3

In vivo biodistribution of mPEG-CDM-modified sEVs. (a) IVIS fluorescence images of glioma-bearing mice injected with DiR-labeled GsEVs or mPEG-CDM-GsEVs at 2, 12, and 24 h post-injection. (b) Statistical analysis of MFI in liver and brain regions from (a). (c) Ex vivo fluorescence images of major organs (liver, brain, kidney, intestine, heart, lung, and spleen) at 2, 12, and 24 h post-injection. (d) Statistical analysis of MFI in liver and brain regions from (c). (e) Representative fluorescence images of liver and brain sections from MCAO mice injected with mCherry-FLAG-labeled IsEVs or mPEG-CDM-IsEVs at 2 and 12 h post-injection. Brain sections were obtained from infarct regions within the ischemic hemisphere. mCherry (red)-labeled sEVs; DAPI (blue)-stained nuclei. Scale bar: 10 μm. (f) Representative immunohistochemical images of liver and brain sections from MCAO mice injected with mCherry-FLAG-labeled IsEVs or mPEG-CDM-IsEVs at 2 and 12 h post-injection. Brain sections were obtained from infarct regions. Scale bar: 50 μm. (g) Statistical analysis of FLAG mean density in liver and brain sections from (f). Data are shown as mean ± SD (n = 5). ∗∗p < 0.01; ∗∗∗p < 0.001. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)