Fig. 10.

GJB2 Inhibits the Infiltration of CD8⁺ T Cells and Promotes Immune Escape. (A-C) Violin plot illuminating the difference of the TIDE score A, Dysfunction score B, and Exclusion score C between the GJB2 high- and low-expression groups. D Box plot displaying differential expression of immune checkpoints between GJB2 high- and low-expression groups. E CD8⁺ T cell migration to lower chambers was quantified following GJB2 overexpression in OC cells. F Flow cytometry analysis of Granzyme B (GZMB) and IFN-γ secretion by CD8⁺ T cells co-cultured with GJB2-overexpressing OC cells (E: T ratio = 5:1). In all statistical plots, data are expressed as the mean ± SD. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001