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. 2005 Sep 19;102(41):14509–14514. doi: 10.1073/pnas.0503691102

Table 2. Effects of P18, P24, and Ap2A on the [Ca2+]i and on the content of thapsigargin-sensitive Ca2+ stores in CD38+/- HeLa cells.

[Cai2+], nM
Cells Control P18 P24 Ap2A
HeLa CD38+ 37 16 57 79
254 123 203 184
HeLa CD38 23 12 44 35
470 366 290 398

Basal [Ca2+]i and thapsigargin-induced Ca2+ release (bold numbers) were measured on FURA 2-loaded CD38+ and CD38 HeLa incubated in the absence (control) or in the presence of 1 M dinucleotides for 18 hr. During this time, partial (≤30%) dinucleotide degradation occurred in CD38+ cell cultures, with production of Ade and hypoxanthine (see Table 3). Mean results from at least eight different determinations are shown; SD ≤ 15% of the mean value.