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. 2025 Mar 15;66(6):2124–2136. doi: 10.1111/epi.18340

FIGURE 2.

FIGURE 2

Comparison of oral ENX‐101 and diazepam in amygdala kindled rats. ENX‐101 was tested in kindled rats at doses of 1, 6, 30, and 100 mg/kg, orally. Diazepam was tested at a dose of 16 mg/kg, orally. (A) Prior to drug treatment, all animals exhibited stage 5 seizures. ENX‐101 treatment caused a dose‐dependent reduction in the seizure severity score, with maximal reduction comparable to that produced by diazepam. (B, C) ENX‐101 treatment caused dose‐dependent reductions in afterdischarge duration as assessed by the EEG recorded from depth electrodes in the amygdala (B) and cortical surface recording (C). The number of animals in each group ranged from 12 to 16 except in the 100 mg/kg ENX‐101 group, which consisted of four animals. Bars indicate mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001. SEM‐ standard error of mean.