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. 2025 May 14;68(11):10599–10618. doi: 10.1021/acs.jmedchem.4c02923

1. Agonist Functional Activity and Binding Affinity for the 8-Carboxamide Derivatives Compound 7 and Compound 12.

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[125I]-DOI ligand. [125I]-DOI: [125I]-2,5-dimethoxy-4-iodoamphetamine. EC50: half maximal effective concentration. E max: maximum effect. Ki: inhibition constant. n.d.: not determined.