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. 2025 May 14;68(11):10599–10618. doi: 10.1021/acs.jmedchem.4c02923

3. IV and PO PK Parameters for 7b in Multiple Species .

IV Parameters (2 mg/kg dose)
Species t1/2 (h) AUC0‑inf (μg·h/mL) Cl (L/h/kg) Vss (L/kg) ClR (L/h/kg)
Mouse 0.41 0.34 5.94 2.44 n.d.
Rat 0.56 ± 0.05 0.77 ± 0.13 2.66 ± 0.47 1.89 ± 0.34 1.44 ± 0.50
Dog 1.38 ± 0.48 1.83 ± 0.08 1.10 ± 0.05 1.41 ± 0.18 0.07 ± 0.08
Cyno 1.49 ± 0.18 2.0 ± 0.18 1.0 ± 0.1 1.80 ± 0.35 0.27 ± 0.19
PO Parameters (5 mg/kg dose)
Species t1/2 (h) tmax (h) Cmax (μg/mL) AUC0‑inf (μg·h/mL) %F
Mouse 0.6 0.25 0.94 0.72 85.6
Rat 1.51 ± 0.66 0.58 ± 0.38 0.57 ± 0.08 2.02 ± 0.13 105 ± 7
Dog 1.90 ± 0.43 0.92 ± 0.95 1.82 ± 0.60 4.13 ± 1.27 90.2 ± 27.8
Cyno 2.07 ± 0.97 2.33 ± 1.53 0.70 ± 0.33 3.58 ± 1.18 71.2 ± 23.4
a

%F: % oral bioavailability. AUC0‑inf: area under the curve extrapolated to infinity. C max: maximum concentration. Cyno: cynomolgus monkey. IV: intravenous. n.d.: not determined. PO: oral administration. t 1/2: half-life. T max: time to maximum concentration.