4. In Vitro Receptor Functional and Binding Data and Cell Permeability Measurements for Racemic 7-Substituted 8‑Carboxamide Analogues 19.

^a[¹²⁵I]-DOI ligand.

^bIn P-gp expressing LLCPK2 cells.

[¹²⁵I]-DOI: [¹²⁵I]-2,5-dimethoxy-4-iodoamphetamine. EC₅₀: half maximal effective concentration. E _max: maximum effect. K_i: inhibition constant. P-gp: p-glycoprotein. n.d.: not determined.