2. Structures, In Vitro Inhibitory Potencies and Selectivities toward hBChE over hAChE, along with Properties Important for Brain Exposure of Lead Compound 2 and Compounds 45, 46, and 3 .

^aThe value is expressed as mean ± SEM of at least two independent experiments.

^bSR, selectivity ratio: IC₅₀(hAChE)/IC₅₀(hBChE).

^cCalculated with ChemOffice 2019.