1. Summary of the Mean Transport Kinetic Data K m (in μM) and V max (in RFU/10 min) for the Indicated NBD-BA via the Carriers NTCP, mNtcp, ASBT, and mAsbt .
|
NTCP
|
mNtcp
|
ASBT
|
mAsbt
|
|||||
|---|---|---|---|---|---|---|---|---|
| K m [μM] | V max [RFU/10 min] | K m [μM] | V max [RFU/10 min] | K m [μM] | V max [RFU/10 min] | K m [μM] | V max [RFU/10 min] | |
| 3α-NBD-TCA (14d) | 20.0 | 25,742 | 9.5 | 52,588 | 11.1 | 32,567 | ||
| 3β-NBD-TCA (14a) | 29.5 | 24,712 | 20.6 | 27,562 | 20.0 | 35,190 | ||
| 3α-NBD-GCA (16d) | 36.8 | 50,932 | 5.2 | 40,662 | 14.5 | 3,945 | 14.5 | 94,113 |
| 3β-NBD-GCA (16a) | 43.1 | 29,152 | 17.2 | 26,736 | 3.5 | 7,175 | ||
| 3β-NBD-TCDCA (14b) | 17.1 | 17,371 | 56.9 | 48,820 | 21.2 | 20,535 | ||
a
Additional 95% confidence intervals for the mean K m and V max values are provided in the Supporting Information. For ASBT, reliable transport kinetic data could only be determined for 3α-NBD-GCA (16d).